Compare prices across insurance and popular pharmacy options — we're a telehealth provider, not a pharmacy, so your prescriptions are always sent to the pharmacy you choose
Systemic estradiol is delivered throughout your body to treat hot flashes, night sweats, and other vasomotor symptoms of menopause.
| Delivery Method | Insurance90-Day Supply | Cost Plus DrugsLIVE90-Day Supply | GoodRx90-Day Cash Pay | HRT Club90-Day Cash Pay |
|---|---|---|---|---|
| Oral Tablet | $10+ | $8.10Best Value | $18-25 | $30 |
| Twice-Weekly Patch | $10+Best Value | $133.48 | $60-180 | $144 |
| Once Weekly Patch | $10+Best Value | $95.36 | $150 | N/A |
| Daily Gel Packet | $10-50Best Value | $91.25 | N/A | $105 |
| Gel Pump (Estragel) | Varies | N/A | $170-250 | $90Best Value |
| Mist (Evamist) | Varies | N/A | $225Best Value | N/A |
These are prices at independent pharmacies — not through MyMenopauseRx. Your specialist will send your prescription to the pharmacy you choose.
Cost Plus Drugs prices updated: April 28, 2026 at 11:00 PM
Our virtual visits work with most major health insurance plans. You only pay your co-pay, coinsurance, or deductible. Don't have insurance? Self-pay visits are available too.
Disclaimer: Cost Plus Drugs prices are fetched in real-time from their public API and include their standard markup (cost + 15% + $5 pharmacy fee + shipping). GoodRx and HRT Club prices are approximate ranges based on publicly available data. Insurance costs depend on your specific plan. MyMenopauseRx does not sell medications — prescriptions are sent to the pharmacy of your choice. Always confirm pricing with your pharmacy before filling a prescription.